Table 1 Summery of SC case reports with aggressive behavior

Skálová A (2010) [17]

16

46

M/F = 9/7

Parotid (13)

Minor glands (3)

2.1

S100

Vimentin

STAT5a

Muc1&4

Mammaglobin

Not seen

CN*(2)

Lung (1)

Present (4)

Died (2)

Seethala (2012) [16]

36

45.7

M/F = 1.4/1

Parotid (26)

Non parotid (10)

1.9–2.5

HMWK

S100

Vimentin

Not seen

CN (4)

Present (3)

Connor (2012) [11]

7

40

M/F = 6/1

Oral cavity (4)

Parotid (2)

Sub mandibular gland (1)

1.86

HMWK

S100

Vimentin

Ck19

Present (3)

Not reported

Not reported

Ito (2012) [26]

1

37

F

Parotid

2.0

HMWK

S100

Vimentin

Present

Not reported

Not reported

Min jung jung (2013) [4]

13

46.4

M/F = 8/5

Parotid (11)

Non-parotid (2)

1.77

(0.7–2.5)

S-100

GCDFP (2/13)

Not seen

HF** (1)

Not reported

Present (3)

Bishop (2013) [7]

11

56

M/F = 4/7

Oral cavity (9)

Sub mandibular (2)

0.9

Mammaglobin

S100

Present (1)

Not reported

Present (1)

Melin-Aldana (2013) [27]

1

14

F

Parotid

3

Not reported

Not seen

PPN***

Not reported

Wenyie Luo (2014) [28]

1

41

F

Hard palate

1.8

Ck7, Ck8/18, S100, BAF47, Vimentin

Present

HF

CN

Not reported

Skálová A (2014) [3]

3

63

All M

Parotid (3)

4–8

S100

EGFR and β-catenin (in high grade component)

Cyclin-D1

Present (1)

HF (3)

Cervical adipose tissue (1)

Present (1)

All 3 died

Majeweska (2014) [23]

7

51.4

M/F = 5/2

Parotid:6

Hard palat:1

2.8

S100

Mammaglobin

Cytokeratin CK7, CK8

STAT5a

Vimentin

Present (2)

HF (2)

CN (3)

Lung (1)

Bone (1)

Present (2)

Died (2)

Todd M (2015) [25]

14

54.5

M/F = 6/8

Parotid:9

Sub mandibular:1

Thyroid:1

Lip:2

Hard palate:1

–

Mammaglobin

S100

Present (1)

HF (1)

CN (2)

Lung (1)

Present (1)

Monica L (2015) [29]

4

50.5

M/F = 1/3

Parotid:1

Buccal mucosa:2

Sub mandibular:1

2.6

Mammaglobin

S100

STAT5

Not seen

HF (1)

CN (1)

Not reported

Nasir Udin (2016) [30]

11

27.5

M/F = 7/5

Parotid:7

Sub mandibular:3

Buccal:1

4.4

S100

EMA

CK7/19

Present (1)

CN (2)

Present (3)

Kensuke Suzuki (2017) [31]

1

74

–

Un known origin

-

S100

GATA3

Not seen

HF

CN

Lung

Not reported

Baghai (2017) [15]

10

46.9

M/F = 6/4

Parotid:9

Minor gland:1

3

Mammaglobin

S100

Present (1)

HF (2)

CN (3)

Bone (1)

Present (3)

Died (2)

Nicole A (2017) [13]

1

44

M

Parotid

3.5

S100

Ck7

Mammaglobin

Present

HF

Pleura

TN****

Died

Huang MD (2017) [20]

1

62

F

Bronchus (minor glands)

8.5

Mammaglobin

S100 (focal)

Not seen

CN

Not reported

David Forner (2018) [24]

13

54

M = F

Parotid (9)

Minor salivary gland (3)

Submandibular (1)

Small in size

S100

Vimentin

Mammaglobin

Ck7

Present (3)

HF (1)

CN (1)

Lung (1)

Present (1)

Rooper (2018) [32]

1

59

F

Submandibular

4.7

S100

Mammaglobin

Not seen

HF

CN

Lung

Bone

Present

Numano (2019) [19]

1

65

F

Parotid

6.9

S100

GATA3

AE1/AE3

EMA

GCDFP(very focal)

Muc 1 (focal)

Present

HF

CN

Lung

Present

Died

Jingjing Sun (2019) [21]

59

63.7 in 3HF

43.2 in conventional

M/F (In conventional) = 4.9/1

All 3 HF were male

Parotid (49)

Submandibular (2)

Minor glands (8)

3.7 HF

2.2 conventional

Ki 67

Present (5)

HF (3)

CN (1)

Lung (4)

Present (7)

Died (1)

Takabatake (2020) [12]

1

54

M

Hard palate

2.5

S100

Vimentin

AE1/3

EMA

Mammaglobin

Not seen

HF

CN

Not reported

Delima (2021) [33]

1

60

M

Secretorty carcinoma ex pleomorphic adenoma

Submandibular gland

–

Mammaglobin

S100 (focal)

Ck7

Adipophilin

Not seen

CN

Not reported

Jingjing Sun (2021) [1]

23

45

M/F = 13/10

Parotid (21)

Submandibular (22)

2.6

(0.8–4.8)

S-100

Mammaglobin

CK7

GATA3

Not seen

CN (5)

Lung (2)

Present (6)

Died (1)

Kensuke Suzuki (2022) [22]

2

37&61

Both M

Parotid (2)

1

S100

STAT5

Mammaglobin

GATA3

EGFR

B-Catenin

Not seen

HF (1)

CN (1)

Present (1)