Fig. 2

Consecutive CT findings from the start of third-line chemotherapy to the end of 17 courses. a–c The lung tumors had progressed after 11 courses of the FOLFIRI + RAM chemotherapy regimen had been administered. d–f The lung tumors had shrunk after three courses of the regorafenib chemotherapy regimen. g–i The lung tumors had shrunk after seven courses of the regorafenib chemotherapy regimen. j–l The lung tumors had shrunk after eleven courses of the regorafenib chemotherapy regimen. m–o The lung tumors had shrunk after 17 courses of the regorafenib chemotherapy regimen. These arrows indicate lung metastases