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Table 1 Patient (P1–P6) characteristics and self-reported assessment. Roman numerals represent number of years spent in education: < 12 years for I; 12 years for II; > 12 years for III. For FSMC, BFS, and ISI, bold denotes severe, bold italics denotes moderate, and italics denotes mild symptoms. For HAD, fDAS, PCL-5, ESS, sQOD-NS, QOLIBRI, and SF-36, bold denotes abnormal and italics denotes near-normal scores. F, female; M, male

From: Outcome of severe COVID-19: spotlight on fatigue, fatigability, multidomain complaints and pattern of cognitive deficits in a case series without prior brain dysfunction and without COVID-19-related stroke and/or cardiac arrest

 

P1

P2

P3

P4

P5

P6

Age (years)

53

57

61

61

67

71

Sex (F/M)

F

M

F

M

M

M

Education level (I–III)

III

II

III

II

II

II

Duration (days) of mechanical ventilation/intensive care unit stay/acute hospitalization/postacute inpatient rehabilitation

18/21/40/53

17/21/29/14

11/12/24/0

50/67/82/37

17/21/29/31

21/31/42/52

Fatigue scales

Fatigue Scale for Motor and Cognitive Functions (FSMC)

      

 Motor 10–50

29

23

31

34

34

22

 Cognitive 10–50

33

22

33

31

32

22

Brugmann Fatigue Scale (BFS)

      

 Physical 0–12

5

0

4

5

5

3

 Mental 0–12

5

2

5

3

5

2

Visual analogue scale for situational mental fatigue (VAS-SMF)

      

 Before cognitive testing 0–10

0

1.8

0.4

2

2.5

0.2

 After cognitive testing 0–10

1.7

4.2

9.7

6.6

8.5

1.2

Visual analogue scale for perceived mental effort (VAS-PME)

      

 0–10

6.1

2.1

9.2

5

5.1

4.1

Psychiatric, neurobehavioral, and somatic questionnaires and scales

Hospital Anxiety and Depression (HAD) scale

      

 Anxiety 0–21

5

6

2

1

9

3

 Depression 0–21

6

1

2

2

1

3

French Dimensional Apathy Scale (f-DAS)

      

 Executive 0–24

12

1

12

1

6

0

 Emotion 0–24

3

2

3

3

3

3

 Initiative 0–24

9

3

8

5

8

5

DSM-5 post-traumatic stress disorder (PTSD) checklist (PCL-5)

      

 0–80

14

6

9

1

8

3

Epworth Sleepiness Scale (ESS)

      

 0–24

10

2

2

7

10

9

Insomnia Severity Index (ISI)

      

 0–28

12

5

1

3

8

7

Visual analogue scale for dyspnoea (VAS-D)

      

 0–10

0

0

3

7

7

3

Visual analogue scale for muscle weakness (VAS-MW)

      

 0–10

0

0

0

6

2

5

Visual analogue scale for olfactory disorders (VAS-OD)

      

 0–10

0

0

0

0

0

9

Short version of the Questionnaire of Olfactory Disorders—Negative Statements (sQOD-NS)

      

 0–21

21

21

21

21

21

19

Quality of Life after Brain Injury questionnaire (QOLIBRI)

      

 0–100

80

93

78

77

80

86

Health-related quality of life (SF-36)

      

 Physical functioning 0–100

75

95

60

75

80

75

 Physical role functioning 0–100

100

100

100

0

100

0

 Bodily pain 0–100

100

100

78

78

80

100

 General health perceptions 0–100

75

70

70

65

60

90

 Vitality 0–100

40

85

55

55

60

80

 Social role functioning 0–100

75

100

100

63

100

75

 Emotional role functioning 0–100

33

100

100

100

33

100

 Mental health 0–100

72

76

80

84

68

92

The Post-COVID-19 Functional Status (PCFS) scale

      

 Before (0–4)

0

0

0

0

1

1

 After (0–4)

1

1

1

2

2

2