Fig. 1From: Treatment of severe metformin-associated lactic acidosis with renal replacement therapy and tris-hydroxymethyl aminomethane: a case reportChange in arterial pH, lactate concentration, and bicarbonate with 33 hours of high flux hemodialysis and 12 hours of intravenous tris-hydroxymethyl aminomethane infusion. After initiating THAM, the patient’s metabolic acidosis improved rapidly. Arrow denoted the time of initiation of THAMBack to article page