Marker (reference range) | Day of illness | |||||||
---|---|---|---|---|---|---|---|---|
5th | 7th | 8th | 10th | 11th | 13th | 17th | 18th | |
Blood analysis | ||||||||
Leukocyte count (4.5–9.5 × 109/L) | – | 5.8 | 8.1 | 8.1 | 11.3 | – | 5.6 | 5.6 |
Neutrophil (1.8–6.3 × 109/L (50–70%)) | – | 5.2 (89%) | 7.1 (87%) | 7.1 (87%) | 10.6 (94%) | – | – | 3.7 (66%) |
Lymphocyte (1.1–3.2 × 109/L (18–40%)) | – | 0.5 (9%) | 0.9 (11%) | 0.9 (11%) | 0.5 (4%) | – | – | 2.2 (31%) |
Neutrophil: Lymphocyte ratio | – | 10.4 | 7.9 | 7.9 | 21.2 | – | – | 2.1 |
Monocytes (0.2–1.0 × 109/L (2–8%)) | – | 0.06 (1%) | 0.07 (1%) | 0.06 (1%) | 0.06 (0.5%) | – | – | 0.12 (2%) |
Eosinophils (0.02–0.5 × 109/L (0–5%)) | – | 0.05 (1%) | 0.06 (0.5%) | 0.06 (0.5%) | 0.05 (0.5%) | – | – | 0.06 (1%) |
Platelets (125–350 × 109/L) | – | 200 | 230 | 200 | 130 | – | – | – |
Erythrocytes (3.8–5.8 × 1012/L) | – | 2.95 | 3.1 | 2.85 | 2.7 | – | 2.98 | 2.98 |
Hemoglobin (115–150 g/L) | – | 85 | 80 | 80 | 75 | – | 89 | 89 |
Alanine transaminase (7–40 U/L) | – | – | 9.1 | 7.4 | 7.4 | 69.5 | 37.2 | 37.2 |
Aspartate transaminase (13–35 U/L) | – | – | 25.6 | 21.0 | 21.04 | 80.4 | 34 | 34 |
Creatinine (45–90 mcmol/L) | – | 54 | 60 | 57 | – | 67 | 119 | 119 |
Urea (2.1 to 8.5 mmol/L) | – | – | 2.4 | 3.2 | – | 5.8 | 10.9 | 10.9 |
Total bilirubin (1.71–20.5 mcmol/L) | – | – | 11.2 | 15.5 | – | 11.3 | 21 | 21 |
Total protein (64–83 g/L) | – | 73 | 56.5 | 55 | 55 | 55 | 60 | 60 |
D-dimer (0.0–0.5 µg/mL) | – | 0.6 | 0.9 | 0.9 | – | – | – | – |
Erythrocyte sedimentation rate (15–25 mm/h) | – | 40 | 25 | 25 | 25 | – | 15 | 15 |
Blood gas pH (7.35–7.45) | – | 7.39 | 7.3 | 7.3 | 7.3 | 7.28 | 7.37 | 7.37 |
Activated partial thromboplastin time (23–30 s) | – | 45 | 45 | 36 | 36 | 29 | 60 | 60 |
Fibrinogen (1.5–3 g/L) | – | 2.2 | 2.2 | 5.5 | 5.55 | 1.99 | 3.1 | 3.1 |
Prothrombin time (11–13.5 s) | – | 17 | 17 | 17 | 17 | - | 20 | 20 |
INR (0.8–1.2) | – | 1.12 | 1.12 | 1.2 | 1.2 | 1.1 | 1.4 | 1.4 |
Urinalysis | – | |||||||
Color (yellow) | – | Yellow | Yellow | – | Yellow | Yellow | Yellow | Yellow |
Appearance (clear) | – | Clear | Clear | – | Clear | – Clear | - | Not clear |
Urinary specific gravity (1.002–1.035) | – | 1.107 | 1.007 | – | 1.022 | 1.017 | 1.018 | 1.018 |
pH (4.5 to 8) | – | – | 5 | – | 5 | 5 | 5 | 5 |
Proteins (les or = 150 mg/l) | – | 69 | 69 | – | 183 | 74 | 70 | 175 |
Erythrocytes (0–5 cells/high-power field) | – | – | – | – | 12 | 15 | 7 | 9 |
Leukocytes (0–5 cells/high-power field | – | 5 | – | – | 2 | 5 | 8 | – |
Epithelial cells (0–20 squamous epithelial cells/high-power field) | – | 3 | 3 | – | 1 | 5 | 12 | 12 |
SARS-CoV-2 PCR | Positive | – | – | – | – | – | – | – |
Blood culture test | – | – | Negative | – | – | – | – | – |
Treatment | Antimicrobal and detoxification therapy | Ritonavir, glucocorticosteroids, anticoagulants; connected to ventilators | Endotracheal intubation | 20% albumin | - | Prone position | Prolonged ventilations with propofol and atracurium, | – |
Outcome | Hospitalization | – | – | Emergency delivery through a cesarean section | – | – | – | Death |