Fig. 1
From: Twenty cases of perennial and seasonal allergic rhinitis treated with LumiMed® Nasal Device
Allergen-induced sensitization. Allergens are processed by antigen presenting cells, such as dendritic cells in the mucosa, and allergen fragments are presented to naïve T cells. These newly activated Th2-type T cells secrete a number of cytokines that drive the proliferation of basophils, eosinophils, and mast cells, furthering allergic inflammation. B cells are also induced to produce allergen-specific IgE that binds to high affinity receptors on basophils and mast cells, facilitating the release of histamines, prostaglandins, and leukotrienes