Fig. 5

The clinical course from the time of the second steroid dose increase. “0 day” indicates the day the PSL dose was increased to 30 mg/day. The clinical activity in UC is shown using the partial Mayo score [6], which consisted of three Mayo subscores, excluding an endoscopic subscore. A moderate UC exacerbation with CMV infection developed, which was treated with PSL and GMA. Although CMV infection was cured, colitis did not improve, and cryptococcal pneumonia occurred. After fluconazole administration, VDZ was initiated for UC. CMV cytomegalovirus, CMV-Ag blood CMV antigenemia, CRP C-reactive protein, CT computed tomography, CS colonoscopy, GMA granulocyte and monocyte adsorption apheresis, IHC immunohistochemistry; PSL prednisolone, UC ulcerative colitis, VDZ vedolizumab