Overlap syndrome of autoimmune hepatitis and primary biliary cholangitis complicated with atypical hepatocellular carcinoma: a case report

Table 1 Paris diagnostic criteria for PBC-AIH overlap syndrome. Adapted to European Association for the Study of the Liver. EASL Clinical Practice Guidelines: management of cholestatic liver diseases. J Hepatol. 2009 Aug;51(2):237–67. https://doi.org/10.1016/j.jhep.2009.04.009

At least 2 of the following:	And at least 2 of the following:
ALP > 2 × ULN (upper limit of normal) or GGT > 5 × ULN	ALT (alanine aminotransferase) > 5 × ULN
AMA > 1:40	IgG (Immunoglobulin G) serum levels > 2 × ULN or smooth muscle autoantibody (SMA) +
Histology: florid bile duct lesion	Histology: moderate or severe interface hepatitis

ALP alkaline phosphatase, AMA anti-mitochondrial antibodies, ALT alanine aminotransferase, IgG Immunoglobulin G, SMA smooth muscle autoantibody, ULN upper limit normal

ISSN: 1752-1947