Fig. 2From: High-grade large cell neuroendocrine carcinoma of the esophagus: a case report and review of the literatureA On low magnification, the biopsy showed islands of tumor separated by fibrovascular septae [hematoxylin and eosin (H&E) ×4]. B The neoplastic cells have large, hyperchromatic nuclei, irregular nuclear membranes, inconspicuous nucleoli, and scant amount of amphophilic cytoplasm (H&E ×20). The presence of significant nuclear molding on the right side of the image was also noted. The tumor cells demonstrate strong and diffuse expression of CD56 (C) and synaptophysin (D)Back to article page