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Table 2 Routes of administration, duration of treatment, and doses of all medications that were given during hospital stay and follow-up

From: Successful use of emapalumab in refractory hemophagocytic lymphohistiocytosis in a child with Chédiak–Higashi syndrome: a case report

Medication

Route

Dose

Duration

Dexamethasone

Intravenous

10 mg/m2/day

Started on 6 June 2019, stopped on 29 November 2019

Restarted on 9 January 2020, stopped on 4 October 2020

Immunoglobulin

Intravenous

7.5 g

Started on 6 June 2019, stopped on 8 November 2020

FK506 (tacrolimus)

Oral

0.5 mg daily

Started on 3 March 2020, stopped on 30 October 2020

Cyclosporine

Oral

30 mg BID

Started on 26 November 2019, stopped on 2 March 2020

Etoposide

Intravenous

90 mg

Started on 26 October 2019, stopped on 6 May 2020

Emapalumab

Intravenous

50 mg

Started on 27 July 2020, stopped on 13 August 2020

Filgrastim

Intravenous

80 µg

Started on 23 October 2019, stopped 15 December 2019

Ganciclovir

Intravenous

75 mg

Started on 17 March 2020, stopped on 2 June 2020

Conditioning medications

 Treosulfan

Intravenous

10 g daily

Started on day -5 (2 September 2020), stopped on day -3 (4 September 2020)

 Fludarabine

Intravenous

30 mg daily

Started on day 6- (1 September 2020), stopped on day -2 (5 September 2020)

Prophylaxis

GVHD prophylaxis

Methotrexate

Intravenous

7.5 mg on days 1, 3, and 6

Started on 8 September 2020, stopped on 13 September 2020

Leucovorin

Intravenous

7.5 mg days 2, 4, and 7

Started on 9 September 2020, stopped on 16 September 2020

FK506 (tacrolimus)

Oral/NGT

0.5 mg daily

Started on day 3 (4 September 2020), stopped on 4 January 2021

Antiviral prophylaxis

Acyclovir

Intravenous

315 mg TID daily

Started on day 3 (4 September 2020), stopped on 9 September 2020

Antifungal prophylaxis

Fluconazole

Oral

100 mg daily

Stared on 17 September 2020, stopped on 30 December 2020

PCP prophylaxis

 Pentamidine

Intravenous

70 mg (once every 4 weeks

Started on day 3 (4 September 2020), stopped on 5 July 2021

Others

Ursodiol

Oral

150 mg, BID

Started on 30 August 2020, stopped on 30 December 2020

  1. BID twice daily, GVHD graft-versus-host-disease, PCP pneumocystis pneumonia, TID three times daily