Table 2 Risk of infertility in women according to chemotherapy drugs [29]
Risk of infertility | Chemotherapy drugs |
|---|---|
High risk (> 80% permanent amenorrhea) | Alkylating agents Nitrogen mustard: cyclophosphamide (≥ 75 g/m2, women < 20 years old), ifosfamide, melphalan, chlorambucil Methanesulfonate: busulfan Triazine: dacarbazine, procarbazine |
Moderate risk (40–60% permanent amenorrhea) | Alkylating agents Platinum analog: cisplatin, carboplatin Nitrogen mustard: cyclophosphamide (woman 29–30 years old) Anthracycline: doxorubicin, epirubicin Moderate risk protocols BEP: bleomycin, etoposide, and cisplatin |
Low risk (< 20% permanent amenorrhea) | Vinca alkaloids: vincristine, vinblastine Antimetabolite: mercaptopurine, methotrexate Cytotoxic antibiotic: bleomycin and actinomycin D |
Very low risk or no risk | Taxanes: docetaxel, paclitaxel Antimetabolite: cytarabine |