Changes in thrombosis-related parameters after AstraZeneca COVID-19 vaccination in a male volunteer: a case report

Table 1 Sequential measurement of thrombosis-related parameters after coronavirus disease-2019 vaccination

Parameters^a	Baseline	Sampling day post vaccination
Parameters^a	Baseline	1	3	7	14	21
Platelet indices
Platelet count (10³/μL)	168	147	159	153	168	169
PDW(fL)	8.7	7.9	8.8	8.5	9.6	8.7
MPV(fL)	8.9	8.6	8.9	8.8	9.0	9.2
P-LCR (%)	15.7	14.1	16.3	15.5	17.6	17.7
Plateletcrit (%)	0.15	0.13	0.14	0.14	0.15	0.16
TRAP aggregation (AUC unit)	101	115	104	108	104	93
Coagulation
Prothrombin time (seconds)	13.3	13.6	13.4	13.3	13.0	13.8
Prothrombin time (%)	99	95	98	99	97	86
Prothrombin time (INR)	1.00	1.03	1.01	1.00	1.02	1.10
APTT (seconds)	36.0	37.1	35.8	36.3	39.1	37.5
vWF activity (%)	185	162	147	160	157	162
vWF antigen (%)	185	183	179	176	168	169
Protein C activity (IU/dL)	91	88	91	92	87	86
Protein C antigen (IU/dL)	69.2	70.4	77.5	81.5	71.6	66
Lupus anticoagulant	–	–	–	–	–	–
Fibrinolysis
Plasminogen (%)	89	86	91	92	85	87
FDP (μg/mL)	< 0.25	< 0.25	< 0.25	< 0.25	< 0.25	< 0.25
D-dimer (μg/mL)	0.31	0.35	0.41	0.40	0.34	0.35

A blood sample for determining baseline values was obtained 1 day before vaccination
PDW platelet distribution width, MPV mean platelet volume, P-LCR platelet-large cell ratio, TRAP thrombin receptor-activating peptide, AUC area under the curve, INR international normalized ratio, APTT activated partial thromboplastin time, vWF von Willebrand factor, FDP fibrinogen degradation product
^aReference normal range (in parentheses): platelet count (130–450 10³/μL), PDW (10.0–20.0 fL), MPV (7.0–13.0 fL), P-LCR (15–35%), TRAP (92.0–151.0 AUC unit), prothrombin time (11.5–15.0 seconds), prothrombin time (70.0–135.0%), prothrombin time (0.84–1.21 INR), APTT (28.0–45.0 seconds), vWF activity (45.6–176.3%), vWF antigen (50.0–160.0%), FDP (0–5.0 μg/mL), D-dimer (0–0.63 μg/mL), protein C activity (72.0–160.0 IU/dL), protein C antigen (73.0–142.0 IU/dL), plasminogen (80.0–120.0 %)

ISSN: 1752-1947