Fig. 1

Sequential measurement of thrombin–antithrombin III complex (TAT), protein S activity, and protein S antigen. The reference range of TAT in the general population has been reported to be < 13.0 ng/mL (see text). Note that TAT levels increased markedly on day 1 post vaccination, but protein S activity and antigen levels decreased during the first few days. The reference range in the general population, provided by the assay kit manufacturer, is 60–140% for protein S activity and 60–150% for protein S antigen