Fig. 2From: Acute kidney injury and long-term renal effects of alectinib in anaplastic lymphoma kinase-positive non-small cell lung carcinoma: a case reportTubular toxicity in a patient on alectinib. Light microscopy reveals massive vacuolar alterations of the cytoplasm of proximal tubular epithelial cells, representing tubular toxicity. No glomerular pathology or vascular changes were seen. Immunofluorescence studies were negative, nor were signs seen of interstitial nephritisBack to article page