Fig. 3

Systolic and diastolic blood pressure (a) and plasma vascular endothelial growth factor levels (b) of the patient before and after binocular anti-VEGF therapies 1 week apart. More than 2 months after anti-VEGF therapy in both eyes, the plasma VEGF levels fell below the detection limit (< 20 pg/ml). On 12 November 2017, cerebral hemorrhage occurred owing to acute hypertension, and the patient was treated with an intravenous injection of nicardipine hydrochloride for 2 days to lower his blood pressure, which promptly returned to a normal level within the same day. On 14 November, 2 days after the stroke, the patients began oral treatment with 80 mg/day telmisartan, which was continued for 3 days. Starting 17 November, the telmisartan dose was reduced to 40 mg/day and continued for 1 year