Fig. 2.

Summary of clinical course. a: Symptoms related to meningitis are shown. CRP levels are shown in the line chart. The x-axis shows day of illness (nonlinear scale). Onset of fever is defined as day 0 of illness. Key days are shown in the bottom line; day 6: initiation of diclofenac sodium; day 17: peak day of serum Cre (red line); day 29: development of uveitis (blue line); day 44: date of discharge; day 71: restart of esomeprazole; day 239: second sampling of IgG avidity test. The same time scale is shared by a, b, c, and d. b: Symptoms related to TIN and uveitis are shown. Serum Cre and percent peripheral eosinophils of the total WBC counts (eosinophils %) are shown in the line chart. ★: Renal biopsy was performed on day 22 of illness. c Duration of each administered drug is shown with rectangles. The patient had been administered esomeprazole for 3 years on day 0. The results of lymphocyte transformation test (LTT)/drug-induced lymphocyte stimulation test (DLST) (performed on day 37 of illness) are shown in parenthesis on the right side. The drug positive for LTT/ DLST is shown in bold line. d Values of Toxoplasma gondii-specific IgG, IgM, and IgG avidity along with the clinical course are shown in a table. The positions of the days of illness are adjusted to match the time scale of a, b, and c. High IgG avidity indicate a distant infection of more than 5 months before. IgG avidity test of day 20 (cryopreserved serum) and day 239 were performed together on day 239