Table 2. Summary of autoimmune pulmonary alveolar proteinosis cases reported in children and adolescents
Case | Age (years)a | Gender | Presenting symptoms | Chronic diseases | Treatment | Outcome | Country |
|---|---|---|---|---|---|---|---|
Latzin et al. [36] | 11b | M | Exertional SOB | NR | WLL | Partially improved | France |
Price et al. [35] | 13 | M | Mild exertional SOB Productive cough FTT | No | WLL Inhaled rhGM-CSF | Improved | Canada |
Yamamoto et al. [34] | 9 | F | Dry cough | No | WLL Inhaled rhGM-CSF | Improved | Japan |
Robinson et al. [33] | 16 | F | Mild SOB | No | WLL Inhaled rhGM-CSF | Improved | USA |
DiBlasi et al. [32] | 13 | M | SOB Cough Fatigue Weight loss | NR | WLL | Improved | USA |
Strickler et al. [31] | 13 | F | SOB Dry cough Fever Exercise intolerance Fatigue | No | WLL | Improved | Chile |
Sideris et al. [30] | 6 | F | NR | Niemann–Pick disease | WLL Inhaled rhGM-CSF | Improved | USA |
Trukalj et al. [29] | 10 | M | Frequent respiratory infections Cough | No | WLL Inhaled rhGM-CSF Bilateral lung transplantation | Improved | Croatia |
Gajewska et al. [28] | 14 | F | Exertional SOB Cough | No | WLL Inhaled rhGM-CSF | Improved | Denmark |
Sirin et al. [27] | 15 | F | Exertional SOB | No | WLL Inhaled rhGM-CSF | Improved | Turkey |
Feld et al. [26] | 16 | F | Exertional SOB Cough Weight loss | Raynaud syndrome | WLL Inhaled rhGM-CSF | Improved | USA |
Meka et al. [25] | 17 | F | Exertional SOB Cough | No | WLL | NR | USA |
Shivji et al. [24] | 13 | F | Exertional SOB | No | WLL | Improved | Canada |
Current report | 15 | M | Exertional SOB Dry cough | No | WLL | Improved | Saudi Arabia |