Fig. 2

Histopathology staining from the biopsy of the patient's stomach through gastroscopy. a Hematoxylin and eosin (H&E) staining with poorly cohesive carcinoma, characterized by signet ring cells. The distribution of cells is diffuse; they can form small groups of bands of gland-like structures with a conspicuous desmoplastic reaction of the stroma. b Immunohistochemical staining showed decreased E-cadherin expression. Positive staining is shown in brown. Representative images of E-cadherin staining demonstrated lower expression of E-cadherin