Fig. 2From: Elevated APOBEC mutational signatures implicate chronic injury in etiology of an aggressive head-and-neck squamous cell carcinoma: a case reportInvasive, p16-negative squamous cell cancer (SCC) of the nasal septum arising in the context of chronic injury. a Hematoxylin and eosin staining of SCC (×4 magnification), b ×10 magnification, c p16 staining demonstrating loss of p16 in tumor (black arrow), with preservation of signal in stroma (red arrow)Back to article page