Table 1 The major clinical features of the 21 previously reported cases of anti-TIF1γ antibody-positive dermatomyositis associated with cancer and our case
Case | Reference/Year | Author | Age (years) | Sex | Chief complaint | Initial diagnosis | Cancer type | Initial CK (U/L) (Maximum value if noted) | Order for treatment | Treatment | Response to internal treatment | Outcome from the diagnosis of DM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | [7], 2013 | Ito | 59 | M | Rash | DM | Gastric cancer IgG4-positive pulmonary inflammatory pseudotumor | 97 | Surgical to internal treatment | Surgical resection (stomach resection and right lower lobectomy) Prednisolone | Remission | Alive but no detailed described |
2 | [8], 2016 | Ogawa | 63 | F | Facial edema | Cancer | Breast cancer | 2326 | Surgical to internal treatment | Surgical resection (partial excision of left breast) Chemoradiotherapy Tacrolimus | ND | Alive at 11 months |
3 | [9], 2016 | Kubecek | 43 | M | Fever Fatigue Myalgia Dysphagia Rash | DM | Breast cancer | 1574 | Internal treatment | Steroid pulse Prednisolone Chemoradiotherapy | No response | ND |
4 | [10], 2016 | Taki | 22 | M | Rash | DM | Extragonadal germ cell tumor | Normal | Internal to surgical treatment | Prednisolone Chemoradiotherapy Surgical resection (tumor resection, left orchiectomy and retroperitoneal lymph node dissection) | Partial response | Alive at 7 months |
5 | [11], 2016 | Murase | 73 | M | Rash Muscle weakness Dysphagia | DM | Gastric cancer | 1266 | Internal treatment | Prednisolone chemotherapy | No response | Dead after 95 days |
6 | [12], 2017 | Matsushita | 66 | F | Dysphagia Muscle weakness Rash | Cancer | Breast cancer | 864 | Internal to surgical treatment | Prednisolone | No response | Dead after few months |
7 | [13], 2017 | Palterer | 78 | F | Muscle weakness Dysphagia Rash Facial edema | DM | Myelodysplastic syndrome | 56 | Internal treatment | Steroid pulse IVIG Methotrexate Prednisolone | Partial response | Dead after 1 year |
8 | [14], 2017 | Kikuchi | 69 | F | Rash | DM | Papillary thyroid cancer Breast cancer Gastric cancer | 536 | Internal to surgical treatment | Prednisolone Surgical resection (Thyroid gland, cervical lymph node, left breast, total stomach and gallbladder resection) | Partial response | Dead after 18 months |
9 | [15], 2017 | Schiffmann | 64 | F | Rash | Cancer | Gastric cancer | Normal | Surgical treatment | Surgical resection (stomach resection) | NA | Alive at least 2 months later |
10 | [16], 2018 | Karino | 72 | M | Rash | DM | Thymic carcinoma | 1576 | Surgical to internal treatment | Surgical resection (thymus resection) Prednisolone | Remission | Alive at least 1 year later |
11 | [17], 2018 | Teraishi | 42 | F | Rash Muscle weakness | DM | Breast cancer (1st) Ovarian cancer (2nd) | 500 (1st) 232 (2nd) | Surgical to internal treatment (1st) Internal to surgical treatment (2nd) | Surgical resection (breast resection) Chemotherapy Prednisolone (1st) Chemotherapy Surgical resection (right salpingo-oophorectomy, omentectomy, and pelvic lymph node dissection) Prednisolone (2nd) | Remission (1st) Remission (2nd) | Alive at 8 years (1st) Alive at least 5 months later (2nd) |
12 | [18], 2019 | Aritomi | 63 | F | Cough Hoarseness | Cancer | Small cell lung cancer | 3272 | Internal treatment | Chemotherapy Prednisolone | No response | Dead after a few months |
13 | [19], 2019 | Kato | 68 | F | Rash | DM | Small cell lung cancer | 252 | Internal to surgical treatment | Chemotherapy | Partial response | ND |
14 | [20], 2019 | Saraya | 58 | M | Rash Cough Muscle weakness Dysphagia | DM | Lung adenocarcinoma | 7833 | Internal treatment | Prednisolone Chemoradiotherapy | No response | Dead after 6 months |
15 | [21], 2019 | Varedi | 65 | F | Myalgia Dysphagia Rash | DM | Pancreatic neuroendocrine tumor | Normal | Internal treatment | Mycophenolate mofetil Hydroxychloroquine Prednisolone Methotrexate Tacrolimus ointment Surgical resection (pancreas resection) | Remission | Alive at 2 months |
16 | [22], 2019 | Shibata | 71 | M | Rash Dysphagia | Cancer | Gastric cancer | 300 (>1000) | Internal treatment | Chemotherapy Nivolumab Prednisolone Steroid pulse IVIG Tacrolimus | No response | Dead after 142 days |
17 | [23], 2020 | Zarkavelis | 72 | M | Muscle weakness Rash | Cancer | Urothelial carcinoma | 1025 | Surgical to internal treatment | Surgical resection (cystoprostatectomy and right ureteronephrectomy) Ipilimumab Nivolumab Prednisolone IVIG | Remission | Alive at least 5 months later |
18 | [24], 2020 | Nakanishi | 80 | F | Dyspnea Dysphagia Muscle weakness | DM | Lymphoepithelioma-like carcinoma | 268 | Internal treatment | Steroid pulse Prednisolone Radiotherapy | Partial response | Alive at least 6 months later |
19 | [25], 2020 | Kuczmarska-Haas | 83 | M | Rash Muscle weakness Dysphagia | DM | Small cell lung cancer | ND | Internal treatment | Prednisolone IVIG Radiotherapy | Partial response | Alive at least 6 months later |
20 | [26], 2020 | Osaki | 64 | M | Rash Muscle weakness | Cancer | Lung adenocarcinoma | 6381 | Internal treatment | Nivolumab Chemotherapy Prednisolone IVIG | No response | Dead after 6 months |
21 | [27], 2020 | Sumazaki | 70 | M | Muscle weakness Myalgia Rash | DM | Esophageal cancer | 6727 | Internal to surgical treatment | IVIG Surgical resection (esophagectomy with 2-field lymph node dissection) Prednisolone | Partial response | Dead after 3 year |
22 | 2020 | Ono | 57 | M | Facial edema Brachial edema Muscle weakness Dysphagia Myalgia Rash | DM | Ascending colon cancer | 5002 (15,667) | Internal to surgical treatment | IVIG Steroid pulse Prednisolone Azathioprine Surgical resection (right hemicolectomy, gastrostomy, and tracheostomy) | Partial response | Dead after 6 months |