Fig. 4From: Acute respiratory failure as initial manifestation of conventional osteosarcoma rich in giant cells: a case reporta Hematoxylin and eosin staining, ×20. b, c Hematoxylin and eosin staining, ×40. Neoplastic lesion composed of a mononuclear background and randomly positioned multinucleated giant cells, with marked variability in size and morphology, nuclei without atypia or mitosis (red arrows). Black arrow Mononuclear cells with cytological atypia and moderate mitosis. d Ki-67 proliferation marker, ×40. Black arrow Mononuclear cells with moderate proliferative indexBack to article page