Fig. 3

Liver biopsy (Day 46). a,b Fibrotic enlargement and piecemeal necrosis of bile canaliculi were observed in the portal area. But lymphocytic infiltration and hepatocellular necrosis of the hepatic lobuleis were rarely observed. (a: hematoxylin-eosin stain, b: azan stain, ×40). c Proliferation of bile canaliculi (hematoxylin-eosin stain, ×400)