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Table 2 Molecular analyses

From: Transformation of a low-grade follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma and a lymphoblastic neoplasm expressing Terminal deoxynucleotidyl Transferase: a case report

Time of disease Type of sample BCR clonality (IGH) IGVH identification Open Reading Frame Percentage of VH homology with germline sequence Percentage of VH homology relative to diagnosis
Diagnosis Lymph node FR1+,a FR2-, FR3- IGHV4–59*01, IGHD5–24*01, IGHJ4*02 Yes 87.27%  
Second progression Lymph node FR1+,a FR2-, FR3- IGHV4–59*01, IGHD5–24*01, IGHJ4*02 Yes 84.55%b 96.9%
Third progression Ascites FR1+,a FR2-, FR3- IGHV4–59*01, IGHD5–24*01, IGHJ4*02 Yes 86.36% 98.9%
  1. a FR1 band of the same size for the three samples
  2. b Detection of two ongoing mutations
  3. BCR B Cell Receptor, IGVH Immunoglobulin Variable region Heavy chain, IGH Immunoglobin Heavy chain, VH immunoglobulin heavy chain variable domain