Transformation of a low-grade follicular lymphoma into a composite lymphoma combining a high-grade B-cell lymphoma and a lymphoblastic neoplasm expressing Terminal deoxynucleotidyl Transferase: a case report

Table 2 Molecular analyses

Time of disease	Type of sample	BCR clonality (IGH)	IGVH identification	Open Reading Frame	Percentage of VH homology with germline sequence	Percentage of VH homology relative to diagnosis
Diagnosis	Lymph node	FR1+,^a FR2-, FR3-	IGHV4–5901, IGHD5–2401, IGHJ4*02	Yes	87.27%
Second progression	Lymph node	FR1+,^a FR2-, FR3-	IGHV4–5901, IGHD5–2401, IGHJ4*02	Yes	84.55%^b	96.9%
Third progression	Ascites	FR1+,^a FR2-, FR3-	IGHV4–5901, IGHD5–2401, IGHJ4*02	Yes	86.36%	98.9%

^a FR1 band of the same size for the three samples
^b Detection of two ongoing mutations
BCR B Cell Receptor, IGVH Immunoglobulin Variable region Heavy chain, IGH Immunoglobin Heavy chain, VH immunoglobulin heavy chain variable domain

ISSN: 1752-1947