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Table 1 Characteristics and outcomes in patients with infective endocarditis and patients with hepatitis B virus with and without antineutrophil cytoplasmic antibodies among all previously reported cohort studies

From: Antineutrophil cytoplasmic antibodies (ANCA)-positive patient with infective endocarditis and chronic hepatitis B virus: a case report and review of the literature

 Patients with IE (n = 274)Patients with HBV (n = 223)P value
Mean age (yr)a58.5549.1 
Males/femalesa135/64132/910.07
ANCA-positive/ANCA-negative73/20142/1810.04
ANCA (by IIF)
 c-ANCA56180.08
 p-ANCA14210.01
 c-ANCA + p-ANCA10.79
ANCA (by ELISA)b
 PR334190.9
 MPO780.21
 PR3 + MPO40.33
Outcomes
 Death c37 (ANCA-positive 10)4<  0.001
  1. Abbreviations: ANCA Antineutrophil cytoplasmic antibodies, c-ANCA Cytoplasmic antineutrophil cytoplasmic antibodies, ELISA Enzyme-linked immunosorbent assay, HBV Hepatitis B virus, IE Infective endocarditis, IIF Indirect immunofluorescence, MPO Myeloperoxidase, p-ANCA Perinuclear antineutrophil cytoplasmic antibodies, PR3 Proteinase 3
  2. aOnly three references have mentioned age and sex in patients with IE among all five references
  3. bPR3- and MPO-ANCAs were detected by ELISA in patients with HBV only in two references
  4. cOnly four references describing patients with IE and two references describing patients with HBV have mentioned outcomes