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Table 2 Identification of influential factors for malignant transformation

From: Significant risk factors for malignant transformation of ovarian endometrioma during dienogest treatment: a case report and retrospective study

  Number Probability P value
Advanced age 94 4.3% 0.0064
Nullipara 113 3.5% 0.0322
Large cyst 18 5.6% 0.1964
Bilateral cysts 70 4.3% 0.3231
Surgical history 81 2.5% 0.1814
Enlargement 70 5.7% 0.0079
Total 174 2.3%  
  1. A multivariate analysis of 174 patients with DNGT was performed to examine the influence of six representative factors that could be collected before starting DNGT, as follows: (1) “advanced age,” defined as patients who started DNGT at 41 years of age or older; (2) nullipara; (3) “large cyst,” defined as patients whose cyst sizes were 8 cm or larger at the start of DNGT; (4) “surgical history,” defined as patients who underwent surgery for the OMA; (5) bilateral cysts; and (6) enlargement. The number of patients with each factor, the probability of MT, and the P values are shown. “Advanced age,” “nullipara,” and “enlargement” were identified as significant risk factors for MT. “Large cyst,” “bilateral cysts,” and “surgical history” were not significant risk factors
  2. Abbreviations: DNGT dienogest therapy, MT malignant transformation, OMA ovarian endometrioma