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Table 1 Patients’ demographics, tumor characteristic, prognostic factor, and clinical outcomes

From: Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report

Authors Year of publication Data Number of patients Histologic subtype Adjuvant therapy Prognostic factors Clinical outcomes
Adem et al. [1] 2004 Single institution study 25 Fibrosarcoma, angiosarcoma, pleomorphic sarcoma > myxofibrosarcoma > leiomyosarcoma > hemangiopericytoma, osteosarcoma, excluding radiation-induced sarcoma and phyllodes tumor 1 adjuvant chemotherapy; 4 adjuvant radiotherapy Tumor size > 5 cm Overall survival 66% Sarcoma-specific survival 70% at 5 years
Bousquet et al. [3] 2007 Multicenter study 103 Angiosarcoma (including radiation-induced sarcoma) >> malignant histiocytofibroma > fibrosarcoma > liposarcoma > leiomyosarcoma > osteogenic sarcoma, excluding phyllodes tumor 11 neoadjuvant chemotherapy; 19 adjuvant chemotherapy; 50 adjuvant radiotherapy Residual tumor after treatment, cellular pleomorphism, angiosarcoma Overall survival 44% at 5 years
Fields et al. [14] 2008 Single institution study 13 Leiomyosarcoma = malignant fibrous histiocytoma = fibrosarcoma > carcinosarcoma = angiosarcoma = epithelioid cell sarcoma = rhabdomyosarcoma, excluding radiation-induced sarcoma and phyllodes tumor 5 adjuvant chemotherapy; 9 adjuvant radiotherapy Tumor size > 5 cm Overall survival 67% at 5 years
Pencavel et al. [4] 2011 Single institution study 63 Angiosarcoma (including radiation-induced sarcoma) > phyllodes tumor > dermatofibrosarcoma protuberans > Leiomyosarcoma > fibrosarcoma = pleomorphic > malignant fibrous histiocytoma = synovial No adjuvant chemotherapy; 24 neoadjuvant radiotherapy Radiation-induced sarcoma Sarcoma-specific survival 93% at 2 years, 78% at 5 years
Toesca et al. [2] 2012 Single institution study 203 Angiosarcoma (including radiation-induced sarcoma) >> stromal sarcoma excluding phyllodes and dermatofibrosarcoma 5 adjuvant chemotherapy; 6 adjuvant radiotherapy Secondary sarcoma (radiation-induced sarcoma, chronic lymphedema) Sarcoma-specific survival 56.6% at 5 years
  1. > greater than, >> much greater than, = equals