Acute kidney injury secondary to thrombotic microangiopathy associated with idiopathic hypereosinophilic syndrome: a case report and review of the literature

Table 5 Reported thrombotic microangiopathy cases: comparative table

Demographics	Our patient	Historical 1 [3]	Historical 2 [3]	Historical 3 [4]
Sex	Male	Male	Male	Male
Age, years	63	15	26	24
Race	Caucasian	African American	Caucasian	Caucasian
CBC at admission
Hemoglobin 12.0–17.5 g/dl	10.0	9.8	13.3	10.7
Platelets 140–450 × 10³/μl	235^a	76	101	130
White cell count 4.5–11.0 × 10³/μl	22.2	23.7	14.7	23.5
Differential count, %
Neutrophils 1.50–7.50 × 10³/μl	4.8	8.3	6.7	Not available
Lymphocytes 1.50–3.70 × 10³/μl	0.9	2.8	2.6	Not available
Monocytes 0.20–1.00 × 10³/μl	0.2	0.7	0.4	Not available
Eosinophils 0.00–0.50 × 10³/μl	16.2	11.1	4.9	18.3
Schistocytes	Positive	Not available	Positive	Positive
Renal function test at admission
Creatinine 0.61–1.24 mg/dl	1.3	10.9	2.2	1.81
GFR	56	Not available	57	50
Percentage eosinophils in bone marrow	60%	80%	44%	37%
Renal biopsy	Glomerular capillary thrombosis Mesangiolysis Endotheliosis Eosinophilic infiltrate	Arterial thrombosis Mesangiolysis Eosinophilic infiltrate	Arteriolar thrombosis Glomerular capillary thrombosis Eosinophilic infiltrate	Arteriolar thrombosis Glomerular capillary thrombosis Eosinophilic infiltrate
Urinalysis
Proteinuria	Negative	Present	Present	Present
Red blood cells/high-power field	20	50	Not available	100
Eosinophils/high-power field	None	None	7	None
Treatment	Prednisone	Prednisone Rituximab	Prednisone Imatinib	Imatinib
Follow-up	At 2 months	At 6 months	At 12 months	At 12 months
Creatinine 0.61–1.24 mg/dl	1.18	5.2	1.8	1.7

ISSN: 1752-1947