Table 1 Reported cases of primary plasmacytoma with multiple lymph node involvement
Author/reference | Patient age/sex | Lymph nodes involved | Ig isotype | Serum monoclonal protein | Bone marrow involvement | Initial therapy | Response to initial therapy | Relapse or persistent disease | Additional therapy | Survival |
|---|---|---|---|---|---|---|---|---|---|---|
Salem et al. [16] | 48 M | Paratracheal, precarinal, subcarinal, aortopulmonary | IgG λ | M-Spike 2.1 g/dL, λ FLC 1613 mg/L | None | Involved field radiation (50 Gy in 25 fractions) | No response | Persistent disease following first-line radiation | VTD-PACE, then auto SCT, then lenalidomide maintenance | In CR 18 months following auto-SCT |
Matsushima et al. [17] | 56 F | Mandibular, cervical, axillary, para-aortic | IgA K | Present, though not quantified | None | Cyclophosphamide and prednisolone (10 courses) | Complete response (CR) | Relapse 6 years following initial CR | Melphalan and prednisolone (10C) | In CR 9 years following initial diagnosis |
Gorodetskiy et al. [18] | 48 F | Diffuse LAD, most prominent at supraclavicular, femoral nodes | IgA K | M-Spike 7.2 g/dL | None | CHOP for 9 cycles | Complete response (CR) | Relapse at 3 months and again at 19 months | Initial relapse treated with 1C CEVD, subsequent treated with 1C CHOEP | In CR 18 years following initial diagnosis |
Menke et al. [6] | Not specified | “Disseminated LN involvement”, specific sites unspecified | Not specified | Not specified | None | Chlorambucil for 8 weeks | Complete response (CR) | None | None | In CR 3 years following initial diagnosis |
Menke et al. [6] | Not specified | “Disseminated LN involvement”, specific sites unspecified | Not specified | Not specified | None | Chlorambucil and prednisone for 8 weeks | No response | Persistent disease following first-line therapy | None | Died of disease 2 months following diagnosis |
Lim et al. [19] | 56 M | Right submental and submandibular | IgG λ | M-Spike 1.6 g/dL | None | Involved field radiation (50 Gy in 25 fractions) | Incompletely reported | Residual mass of uncertain viability to be monitored with serial PET | None | Duration of survival not reported |
Lin et al. [20] | 58 F | Bilateral cervical | K light chain | Present, though not quantified | None | Excision | Complete response (CR) | None | None | In CR at 1 year following excision |