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Table 1 Reported cases of primary plasmacytoma with multiple lymph node involvement

From: Primary extramedullary plasmacytoma with diffuse lymph node involvement: a case report and review of the literature

Author/reference Patient age/sex Lymph nodes involved Ig isotype Serum monoclonal protein Bone marrow involvement Initial therapy Response to initial therapy Relapse or persistent disease Additional therapy Survival
Salem et al. [16] 48 M Paratracheal, precarinal, subcarinal, aortopulmonary IgG λ M-Spike 2.1 g/dL, λ FLC 1613 mg/L None Involved field radiation (50 Gy in 25 fractions) No response Persistent disease following first-line radiation VTD-PACE, then auto SCT, then lenalidomide maintenance In CR 18 months following auto-SCT
Matsushima et al. [17] 56 F Mandibular, cervical, axillary, para-aortic IgA K Present, though not quantified None Cyclophosphamide and prednisolone (10 courses) Complete response (CR) Relapse 6 years following initial CR Melphalan and prednisolone (10C) In CR 9 years following initial diagnosis
Gorodetskiy et al. [18] 48 F Diffuse LAD, most prominent at supraclavicular, femoral nodes IgA K M-Spike 7.2 g/dL None CHOP for 9 cycles Complete response (CR) Relapse at 3 months and again at 19 months Initial relapse treated with 1C CEVD, subsequent treated with 1C CHOEP In CR 18 years following initial diagnosis
Menke et al. [6] Not specified “Disseminated LN involvement”, specific sites unspecified Not specified Not specified None Chlorambucil for 8 weeks Complete response (CR) None None In CR 3 years following initial diagnosis
Menke et al. [6] Not specified “Disseminated LN involvement”, specific sites unspecified Not specified Not specified None Chlorambucil and prednisone for 8 weeks No response Persistent disease following first-line therapy None Died of disease 2 months following diagnosis
Lim et al. [19] 56 M Right submental and submandibular IgG λ M-Spike 1.6 g/dL None Involved field radiation (50 Gy in 25 fractions) Incompletely reported Residual mass of uncertain viability to be monitored with serial PET None Duration of survival not reported
Lin et al. [20] 58 F Bilateral cervical K light chain Present, though not quantified None Excision Complete response (CR) None None In CR at 1 year following excision
  1. Seven cases of primary plasmacytoma involving multiple lymph nodes are reported in the literature. Two of these cases (Lim et al. and Lin et al.) were localized enough to be treated via surgery or radiation alone. Thus, only five cases describe disease sufficiently disseminated as to require systemic chemotherapy
  2. Abbreviations: C cycle, CEVD lomustine, etoposide, vinblastine, dexamethasone, CHOP doxorubicin, cyclophosphamide, vincristine, prednisolone, CHOEP doxorubicin, cyclophosphamide, vincristine, etoposide, prednisolone, CR complete remission, F female, FLC free light chain, LAD lymphadenopathy, LN lymph node, M male, M-Spike monoclonal spike, PET positron emission tomography, SCT stem cell transplantation,VTD-PACE dexamethasone, thalidomide, cisplatin, doxorubicin, cyclophosphamide, etoposide, bortezomib