Table 1 Medical history timeline

Age

19 years

21 years

25 years

27 years

27 years

28 years

29 years

30 years

Disease

AS (HLA-B27 negative)

MVA

OA

OA grade IV

OA grade IV

Symptoms

Spinal pain involving shoulders and interscapular region and lower lumbar spine

Severe fracture of right knee

Effusion, reduced range of movement, low grade enthesitis, bilateral grade 2 sacroiliitis, peripheral arthritis

Effusion, reduced range of movement, low grade enthesitis, bilateral grade 2 sacroiliitis, peripheral arthritis

Effusion, reduced range of movement, low grade enthesitis, bilateral grade 2 sacroiliitis, peripheral arthritis, OA of hips and right knee

Diagnosis

MRI

CT scan and ultrasound scan

X-ray

Medication as per medical history

Data not available

Data not available

Allegron (nortriptyline; 25 mg X 2)

Xenacort A (Triamcinolone acetonide)40

Allegron (nortriptyline; 25 mg X 2)

Allegron (nortriptyline; 25 mg X 1)

Allegron (nortriptyline)

Mirtazon (mirtazapine; 30 mg)

Ketoprofen (200 mg)

Mirtazon (mirtazapine; 30 mg)

Mirtazon (mirtazapine; 30 mg)

Mirtazon (mirtazapine)

Cymbalta (duloxetine; 60 mg X 5)

Cymbalta (duloxetine; 60 mg X 3)

Cymbalta (duloxetine; 60 mg X 3)

Cymbalta (duloxetine; 60 mg X 3)

Cymbalta (duloxetine)

Valdoxan (agomelatine; 25 mg X 3)

Endone (oxycodone; 5 mg X 3)

Diazepam (5 mg X 3)

Endone (oxycodone; 5 mg X 3)

Endone (oxycodone; 5 mg X 3)

Endone (oxycodone)

Tramadol (50 mg X 2, 150 mg X 1)

Lyrica (pregabalin; 150 mg X2)

Endone (oxycodone; 5 mg X 4)

Lyrica (pregabalin; 150 mg X 5)

Lyrica (pregabalin; 150 mg X 3)

Lyrica (pregabalin)

Lyrica (pregabalin; 300 mg X 2)

Nexium (esomeprazole; 40 mg)

Lyrica (pregabalin; 150 mg X 2)

Nexium (esomeprazole; 40 mg)

Nexium (esomeprazole; 40 mg)

Nexium (esomeprazole)

Orudis SR (ketoprofen; 200 mg X 3)

Nexium (esomeprazole; 40 mg)

Orudis SR (ketoprofen; 200 mg X 3)

Orudis SR (ketoprofen; 200 mg)

Orudis (ketoprofen)

Oxycontin (oxycodone; 30 mg)

Oxycontin (oxycodone; 30 mg)

Oxycontin (oxycodone; 30 mg)

Oxycontin (oxycodone)

Panadol Osteo (paracetamol; 665 mg PRN)

Remeron (mirtazapine; 30 mg)

Panadol Osteo (paracetamol; 665 mg PRN)

Panadol Osteo (paracetamol; 665 mg PRN)

Panadol Osteo (paracetamol)

Somac (pantoprazole; 20 mg X 1)

Seroquel (quetiapine; 25 mg X 3)

Panadol Osteo (paracetamol; 665 mg × 3) PRN)

Seroquel (quetiapine; 25 mg X 3)

Seroquel (quetiapine; 25 mg X 3)

Seroquel (quetiapine; 25 mg X 3)

Seroquel (quetiapine; 25 mg X 3)

Seroquel (quetiapine; 25 mg)

Ostelin (ergocalciferol; 25 mcg)

Ostelin (ergocalciferol; 25 mcg)

Ostelin (ergocalciferol)

Ostelin (ergocalciferol)

Pantoprazole

Pantoprazole

Pantoprazole

Physiotens(moxonidine

Physiotens (moxonidine)

Physiotens (moxonidine

Valium (diazepam; 5 mg PRN)

Valium (diazepam; 5 mg PRN)

Valium (diazepam)

Methadone (10 mg X 6)

Methadone (10 mg X 6)

Methadone

Methadone (10 mg X 5)

Uremide (furosemide)

Uremide (furosemide)

Uremide (furosemide)

Tresos B multivitamin

Tresos B multivitamin

Tresos B multivitamin

Tresos B multivitamin

BioMagnesium high dose

BioMagnesium high dose

BioMagnesium high dose

BioMagnesium high dose

Humira (adalimumab) injection

Humira (adalimumab) injection

Humira (adalimumab) injection

Oroxine (levothyroxine)

Oroxine (levothyroxine)

Oroxine (levothyroxine)

Walking aid

Wheelchair usage

Wheelchair usage

Wheelchair usage

Stick/Walker

Intervention