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Table 2 Reported cases of multiple myeloma coexisting with Cushing syndrome

From: Multiple myeloma concealed by adrenal Cushing syndrome: a case report and review of the literature

Author and Reference number

Year

Patient

Diseases

Monoclonal gammopathy type

Treatment sequence

Treatment outcomes

Kinugawa et al. [5]

1989

55-year-old woman

MM with Cushing disease

IgG-lambda

- Low dose of o,p’-DDD to control hypercortisolemia

- MP regimen for treatment of MM

- After cortisol level was normalized, MM symptoms were exacerbated

Kebapclar et al. [6]

2007

60-year-old man

MM with subclinical Cushing syndrome

IgA

- VAD regimen for MM treatment

- Not applicable

This case

2018

33-year-old woman

MM with left cortisol-producing adrenal adenoma

Kappa light chain

- VCD regimen with subsequent ASCT for treatment of MM

- Left adrenalectomy

- MM in complete response

- CS in remission

  1. CS Cushing syndrome, MM multiple myeloma, MP melphalan/prednisolone, o,p’-DDD mitotane, VAD vincristine/doxorubicin/dexamethasone, VCD bortezomib/cyclophosphamide/dexamethasone, ASCT autologous stem cell transplantation