| | | Long-duration operation | | Massive bleeding | |
|---|
Risk factors | Number | OR (95% CI) | P value | OR (95% CI) | P value |
|---|
Large leiomyoma | 33 | 1.7 (0.6–4.7) | NS | 2.4 (0.7–7.6) | NS |
Multiple leiomyoma | 46 | 6.1 (0.6–62.4) | NS | 5.2 (0.5–55.0) | P < 0.05 |
Subserosal leiomyoma | 12 | 0.6 (0.1–7.1) | NS | 0.7 (0.1–8.6) | NS |
Posterior leiomyoma | 31 | 0.4 (0.1–1.5) | NS | 0.9 (0.3–2.7) | NS |
Heavy leiomyoma | 13 | 2.9 (0.9–9.7) | NS | 2.9 (0.9–9.7) | NS |
Higher BMI | 12 | 1.6 (0.4–7.2) | NS | 1.9 (0.4–9.0) | NS |
Advanced age | 25 | 2.9 (1.1–8.2) | NS | 0.7 (0.2–2.7) | NS |
Anemia | 9 | 0.9 (0.1–11.0) | NS | Impossible to calculate | NS |
Multiparity | 10 | 0.8 (0.1–9.4) | NS | 0.9 (0.1–11.3) | NS |
GnRHa | 60 | 2.3 (0.2–24.8) | NS | 2.0 (0.2–22.0) | NS |
- Abbreviations: BMI Body mass index, GnRHa Gonadotropin-releasing hormone analogue, OR Odds ratio, CI Confidence interval, NS Not significant
- Ten factors were defined as follows: (1) “large leiomyoma,” defined as a dominant leiomyoma ≥ 8 cm; (2) “multiple leiomyomas,” defined as three or more leiomyomas; (3) “subserous leiomyoma,” defined as a dominant subserous leiomyoma; (4) “posterior leiomyoma,” defined as dominant posterior leiomyoma; (5) “heavy leiomyoma,” defined as total weight of the resected leiomyomas ≥ 300 g; (6) “higher BMI,” defined as BMI ≥ 25 kg/m2; (7) “advanced age,” defined as age ≥ 40 years; (8) “anemia,” defined as serum hemoglobin level < 10 g/dl; (9) “multiparity,” defined as a patient who has delivered at least once; and (10) “GnRHa,” defined as a patient who was administered GnRHa before surgery. The relationship between “long-duration operation” or “massive bleeding,” which were defined as 120 minutes or 275 ml, respectively, and these ten factors was assessed by multivariate analysis. In this analysis, only “multiple leiomyomas” had the significant impact on the amount of blood loss (P < 0.05). “Multiple leiomyomas” had also the tendency of increasing the risk of “long-duration operation” (P = 0.062) and “higher BMI” showed a tendency of increasing the risk of “massive bleeding” (P = 0.068)
