Table 1 Abbreviated Japanese Ministry of Health and Welfare guidelines for the diagnosis of cardiac sarcoidosis

Histological

Non-caseating granuloma on myocardial biopsy

N/A

N/A

Clinical

Myocardial biopsy does not confirm cardiac sarcoidosis.

and

Two major criteria or

One major and two minor criteria present.

• Advanced atrioventricular block

• Basal thinning of the intraventricular septum

• Positive cardiac ⁶⁷Ga uptake

• LVEF < 50%

• Abnormal ECG findings

• Abnormal TTE findings

• Nuclear medicine perfusion defect by ²⁰¹Tl or ⁹⁹Tc myocardial scintigraphy

• Delayed enhancement of myocardium on MRI-GAD

• Endomyocardial biopsy showing interstitial fibrosis or monocyte infiltration