Table 1 International Myeloma Working Group diagnostic criteria of solitary plasmacytoma of bone, extramedullary plasmacytoma, and multiple solitary plasmacytomas (primary or recurrent) [3]
Diagnosis | Criteria |
|---|---|
Solitary plasmacytoma of bone (SPB) | No M-protein in serum and/or urine* Single area of bone destruction due to clonal plasma cells Bone marrow not consistent with multiple myeloma (plasma cells <5%) Normal skeletal survey (and magnetic resonance imaging of spine and pelvis if done) No related organ or tissue impairment (no end organ damage other than solitary bone lesion)* |
Extramedullary plasmacytoma (EMP) | No M-protein in serum and/or urine* Extramedullary tumor of clonal plasma cells Normal bone marrow Normal skeletal survey No related organ or tissue impairment (end organ damage including bone lesions)* |
Multiple solitary plasmacytomas (primary or recurrent) | No M-protein in serum and/or urine* More than one localized area of bone destruction or extramedullary tumor of clonal plasma cells which may be recurrent Normal bone marrow Normal skeletal survey and magnetic resonance imaging of spine and pelvis if done No related organ or tissue impairment (no end organ damage other than the localized bone lesions) |