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Table 1 International Myeloma Working Group diagnostic criteria of solitary plasmacytoma of bone, extramedullary plasmacytoma, and multiple solitary plasmacytomas (primary or recurrent) [3]

From: Strategy for the treatment and follow-up of sinonasal solitary extramedullary plasmacytoma: a case series

Diagnosis Criteria
Solitary plasmacytoma of bone (SPB) No M-protein in serum and/or urine*
Single area of bone destruction due to clonal plasma cells
Bone marrow not consistent with multiple myeloma (plasma cells <5%)
Normal skeletal survey (and magnetic resonance imaging of spine and pelvis if done)
No related organ or tissue impairment (no end organ damage other than solitary bone lesion)*
Extramedullary plasmacytoma (EMP) No M-protein in serum and/or urine*
Extramedullary tumor of clonal plasma cells
Normal bone marrow
Normal skeletal survey
No related organ or tissue impairment (end organ damage including bone lesions)*
Multiple solitary plasmacytomas (primary or recurrent) No M-protein in serum and/or urine*
More than one localized area of bone destruction or extramedullary tumor of clonal plasma cells which may be recurrent
Normal bone marrow
Normal skeletal survey and magnetic resonance imaging of spine and pelvis if done
No related organ or tissue impairment (no end organ damage other than the localized bone lesions)
  1. *A small M-component may sometimes be present
  2. Modified by International Myeloma Working Group. “Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group.” Br J Haematol 2003;121:749–57 [3]