Table 1 Laboratory and diagnostic data
From: Adult cancer-related hemophagocytic lymphohistiocytosis – a challenging diagnosis: a case report
Characteristic (reference laboratory value) | Baseline | Peak of liver enzyme abnormalities | Admission | Steroid initiation | 1 week post-steroid | 2 weeks post-admission |
|---|---|---|---|---|---|---|
White blood cell (4–11×103/uL) | 5.5 | 4.0 | 5.0 | 8.5 | 4.8 | 41.0 |
Hemoglobin (14.0–18.0 gm/dL) | 11.0 | 9.0 | 11.1 | 10.8 | 9.5 | 13.1 |
Platelet (140–440 K/uL) | 164 | 109 | 60 | 75 | 29 | 96 |
Prothrombin time (12.7–15.0 seconds) | 15.7 | 20.6 | 22.5 | 35.7 | 24.6 | 26.3 |
International normalization ratio (0.90–1.20) | 1.25 | 1.80 | 2.02 | 3.76 | 2.22 | 2.43 |
Partial thromboplastin time (24.7–35.9 seconds) | 42.0 | 37.7 | 31.6 | 45.1 | 30.1 | 32.9 |
Fibrinogen (mg/dL) | 452 | 166 | 141 | 173 | 155 | |
Albumin (g/dL) | 2.9 | 2.3 | 2.3 | 2.2 | 3.3 | 4.0 |
Aspartate aminotransferase (15–46 U/L) | 150 | 807 | 395 | 314 | 136 | 145 |
Alanine aminotransferase (7–56 U/L) | 67 | 319 | 54 | 53 | 26 | 39 |
Alkaline phosphatase (38–126 U/L) | 123 | 139 | 432 | 350 | 182 | 187 |
Gamma-glutamyl transferase (8–78 U/L) | 42 | 148 | 291 | 252 | ||
Serum lactate dehydrogenase (U/L) | 2372 | 3879 | 3449 | 2769 | 3867 | |
Ferritin (30–400 ng/mL) | 28,942 | 10,283 | 6031 | 5863 | ||
Serum triglyceride level (≤1500 mg/dL) | 167 | 212 | 101 | |||
NK-cell activity (7–125 LU30) | 5 | |||||
CD25 (<1033 pg/mL) | 3910 | |||||
IL-1 (<1.0 pg/mL) | 1.8 | |||||
IL-6 (<5.0 pg/mL) | 27 | |||||
IFN-y (<2.0 pg/mL) | <0.4 | |||||
Tumor necrosis factor (1.2–15.3 pg/mL) | 20.9 |