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Table 1 Clinicopathological differential features of primary lung large cell neuroendocrine carcinoma and primary thymic large cell neuroendocrine carcinoma

From: Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report

  Lung LCNEC Thymic LCNEC
Association with tobacco smoking Yes No
Imaging Peripheral tumor, rarely invading mediastinal structures Anterior mediastinal tumor
Immunohistochemistry:
 CK7 +
 TTF-1 +
 PAX8 +
 CD117 +/− +/−
  1. CK cytokeratin, LCNEC large cell neuroendocrine carcinoma, TTF-1 thyroid transcription factor-1, + usually positive, − usually negative