Table 1 Clinicopathological differential features of primary lung large cell neuroendocrine carcinoma and primary thymic large cell neuroendocrine carcinoma
From: Thymic large cell neuroendocrine carcinoma – a rare and aggressive tumor: a case report
Lung LCNEC | Thymic LCNEC | |
|---|---|---|
Association with tobacco smoking | Yes | No |
Imaging | Peripheral tumor, rarely invading mediastinal structures | Anterior mediastinal tumor |
Immunohistochemistry: | ||
CK7 | + | − |
TTF-1 | + | − |
PAX8 | − | + |
CD117 | +/− | +/− |