Table 1 Clinical and hematological features of both patients
Mutation | ||
|---|---|---|
c.394A > T | c.783-1_784delGTG | |
Age (years) | 79 | 82 |
Gender | Female | Male |
Complete blood count | ||
Hemoglobin, g/dL | 10.3 | 10.82 |
Hematocrit, % | 30.0 | 33.0 |
Mean corpuscular volume (fL) | 88.08 | 92.5 |
Leukocytes (×109/L) | 5.5 | 4.59 |
Neutrophils(×109/L) | 3.3 | 0.77 |
Platelets (×109/L) | 208 | 113.2 |
Karyotype | 46,XX | 46,XY |
Bone marrow blasts | 0.5% | 2.2% |
Bone marrow fibrosis | Degree II | Without fibrosis |
Bone marrow iron | Normal | Normal |
Bone marrow cellularity | Hypocellular | Hypercellular |
CD34 immunoreactivity | Negative | Negative |
p53 immunohistochemistry | Negative | Positive (2%) |
Transfusion dependence | No | No |