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Table 1 Classification of non-bacterial osteitis

From: Classical Hodgkin lymphoma masquerading as chronic recurrent multifocal osteomyelitis: a case report

Major diagnostic criteria

Minor diagnostic criteria

1. Radiographically proven osteolytic and/or osteosclerotic bone lesion

2. Multifocal bone lesions

3. Pustulosis palmoplantaris or psoriasis

4. Sterile bone biopsy with signs of inflammation and/or fibrosis and sclerosis

A. Normal blood count and good general state of health

B. CRP and ESR mildly-to-moderately elevated

C. Observation time longer than 6 months

D. Hyperostosis

E. Associated with other autoimmune diseases apart from pustulosis palmoplantaris or psoriasis

F. Grade I or II relatives with autoimmune or auto-inflammatory disease, or with NBO

  1. CRP C-reactive protein, ESR erythrocyte sedimentation rate, NBO non-bacterial osteitis. (2 – As proposed by Jansson et al. [5], Classification of Non-Bacterial Osteitis: Retrospective study of clinical, immunological and genetic aspects in 89 patients. Rheumatology (2007), 46 (1): 154–160. Permission granted from Oxford University Press.)
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Journal of Medical Case Reports

ISSN: 1752-1947