Table 3 Colchicine triggered simvastatin-induced myopathy: review of the literature
Case reports | Age in years | Sex | Muscle symptoms | Simvastatin | Colchicine |
|---|---|---|---|---|---|
Hsu et al. 2002 [17] | 70 | M | Symmetrical proximal muscle weakness 3–4/5 | – | 0.5 mg daily |
Baker et al. 2004 [18] | 79 | M | Severe weakness | 40 mg daily | 0.6 mg daily |
Justiniano et al. 2007 [16] | 61 | F | Rhabdomyolysis | 40 mg daily | 0.6 mg daily |
Sahin et al. 2008 [15] | 30 | M | Proximal muscle weakness upper and lower extremities 2–3/5 | 20 mg daily | 1.5 mg daily |
Oh et al. 2012 [13] | 84 | M | Symmetrical proximal muscle weakness | 40 mg daily | 1 mg (first 3 days); 0.5 mg daily |
Medani and Wall 2016 [14] | 60 | M | Muscle weakness 4/5 in all limbs except 5/5 in hip extensor | – | 1.5 mg daily |
Current case | 70 | M | Rhabdomyolysis | 40 mg daily | 0.5–1 mg as required |