Fig. 1

Color fundus photographs and fluorescein angiograms. a Fundus photographs of the patients (PA and PB are the family members depicted in Fig. 2). The images for PA were taken in 2007 and those for PB in 2014. b Fluorescein angiograms for PA taken in 1996 and PB in 2014. Choroidal neovascularization, hyperpigmentation and reticular pseudodrusen were seen as representative markers for classical wet type of age-related macular degeneration. PA Patient A, PB Patient B