Table 1 Medication history
Date of visit | Medication | Dosage and route | Duration of treatment | Response to treatment/concurrent events |
|---|---|---|---|---|
April, year 1 | Prednisolone | 80mg/day orally | 1 month | No response |
May, year 1 | Rituximab | 800U/week | 4 weeks | No response |
Dexamethasone | 40mg/day pulsed | 4 days/week every two weeks up to four cycles | No response | |
July, year 1 | Azathioprine | 100mg/day | 3 months | No response |
Danazol | 200mg/three times a day, orally | 3 months | No response | |
October, year 1 | Previous regimen + Cellecept®(mycophenolate mofetil) | 1g/three times a day | 4 months | No response |
February, year 2 | Endoxan® (cyclophosphamide) | 1g/ every 3 weeks | (four cycles) | No response |
April, year 2 | Colchicine | 1mg/day | 2 months | No response |
Chloroquine | 1 tablet twice a day | 2 months | No response | |
June, year 2 | Danazol | 200mg/three times a day | 3 months | No response |
Prednisolone | 50mg Every other day | 3 months | Continued to present as maintenances therapy | |
September, year 2 | Intravenous immunoglobulin | 1g/kg/day for 2 days | Four cycles | Platelet elevation to 300,000 for 2 weeks |
January, year 3 | Sirolimus | Day 1: 6mg Maintenance dose: 2mg/day | 1 month | First neurological attack |
February, year 3 | Intravenous immunoglobulin | 1g/kg/day | For 2 days 3 cycles | Transient improvement of platelet count |
March, year 3 | Sirolimus | 2mg/d | 11 months | No response |
Oncovin®(vincristine) | 2mg/week intravenously | For 2 weeks | Side effects: paresthesias, severe abdominal pain | |
April, year 3 | Sandimmune® (cyclosporine) | 900mg orally/day | – | Intolerance |
| Â | Chlorambucil | 14mg/day for 28 days | Two cycles | No response |