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Table 1 Medication history

From: An unusual occurrence of Kleine-Levin syndrome in a man with refractory immune thrombocytopenic purpura: a case report

Date of visit Medication Dosage and route Duration of treatment Response to treatment/concurrent events
April, year 1 Prednisolone 80mg/day orally 1 month No response
May, year 1 Rituximab 800U/week 4 weeks No response
Dexamethasone 40mg/day pulsed 4 days/week every two weeks up to four cycles No response
July, year 1 Azathioprine 100mg/day 3 months No response
Danazol 200mg/three times a day, orally 3 months No response
October, year 1 Previous regimen + Cellecept®(mycophenolate mofetil) 1g/three times a day 4 months No response
February, year 2 Endoxan® (cyclophosphamide) 1g/ every 3 weeks (four cycles) No response
April, year 2 Colchicine 1mg/day 2 months No response
Chloroquine 1 tablet twice a day 2 months No response
June, year 2 Danazol 200mg/three times a day 3 months No response
Prednisolone 50mg Every other day 3 months Continued to present as maintenances therapy
September, year 2 Intravenous immunoglobulin 1g/kg/day for 2 days Four cycles Platelet elevation to 300,000 for 2 weeks
January, year 3 Sirolimus Day 1: 6mg Maintenance dose: 2mg/day 1 month First neurological attack
February, year 3 Intravenous immunoglobulin 1g/kg/day For 2 days 3 cycles Transient improvement of platelet count
March, year 3 Sirolimus 2mg/d 11 months No response
Oncovin®(vincristine) 2mg/week intravenously For 2 weeks Side effects: paresthesias, severe abdominal pain
April, year 3 Sandimmune® (cyclosporine) 900mg orally/day Intolerance
  Chlorambucil 14mg/day for 28 days Two cycles No response