Table 1 Diagnostic criteria for neurofibromatosis type 1 according to the National Institutes of Health [8]
From: Breast cancer associated with neurofibromatosis type 1: a case series and review of the literature
Diagnostic criteria for neurofibromatosis type 1 | |
|---|---|
1. | Six or more café-au-lait macules over 5mm in diameter in prepubertal individuals and over 15mm in diameter in postpubertal individuals. |
2. | Two or more neurofibromas of any type or one plexiform neurofibroma. |
3. | Freckling in the axillary or inguinal region. |
4. | Optic glioma. |
5. | Two or more Lisch nodules (iris hamartomas). |
6. | A distinctive osseous lesion such as sphenoid dysplasia or thinning of the long bone cortex with or without pseudarthrosis. |
7. | A first-degree relative (parent, sibling or offspring) with neurofibromatosis type 1 as diagnosed by the above criteria. |