Table 3 Results of multichannel impedance-pH monitoring during pucalopride-treatment[7]

MII and/or pH monitoring during treatment with prucalopride

Medication during monitoring:

Medication during monitoring:

Medication during monitoring:

Medication during monitoring:

- Pantoprazole 40mg per day

- Pantoprazole 40mg per day

- Omeprazole 20mg per day

- Prucalopride 2mg per day

+ Prucalopride 2mg per day

+ Prucalopride 2mg per day

+ Prucalopride 2mg per day

Acid reflux time:

0.1%

Acid reflux time:

0.9%

Acid reflux time:

1.2%

Acid reflux time:

1.9%

Overall reflux episodes:

46

Overall reflux episodes:

108

Overall reflux episodes:

83

Overall reflux episodes:

59

Mixed or liquid reflux episodes:

5

Mixed or liquid reflux episodes:

100

Mixed or liquid reflux episodes:

74

Mixed or liquid reflux episodes:

40

Gaseous reflux episodes:

41

Gaseous reflux episodes:

8

Gaseous reflux episodes:

9

Gaseous reflux episodes:

19

Acid reflux episodes:

17

Acid reflux episodes:

32

Acid reflux episodes:

26

39

Non- and/or weakly acid reflux episodes:

29

Non- and/or weakly acid reflux episodes:

76

Non- and/or weakly acid reflux episodes:

57

Acid reflux episodes: Non- and/or weakly acid reflux episodes:

20

*Scale 0 to10: 0 = none; 10 = unbearable

Subjective symptom scores*

Subjective symptom scores*

Subjective symptom scores*

Subjective symptom scores*

- Heartburn + Regurgitation: 3

- Heartburn + Regurgitation: 5

- Regurgitation: 3

- Heartburn, Globus, Bloating: 4

Limitation of daily life: 3

Limitation of daily life: 5

Limitation of daily life: 3

Limitation of daily life: 9

SI: positive for heartburn and regurgitation

SI: positive for heartburn, negative for regurgitation

SI: negative for regurgitation

SI: negative for heartburn, globus and bloating