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Table 1 Clinical features of four diabetic patients with known history of herpes zoster, who never exhibited insulin-induced localized involutional lipoatrophy (LIL)

From: Insulin-induced localized lipoatrophy preceded by shingles (herpes zoster): a case report

Zoster patients without insulin-induced LIL

Gender

male

female

male

female

Age, years

56

60

59

79

Type of diabetes

type-1

type-1

type-1

type-2

Duration of diabetes, years

37

36

28

19

Diabetic complications1

none

none

none

none

Insulin therapy

injections

injections

CSII2

injections

Application of Humalog™

no

no

no

no

Varicella-zoster IgG, mU/ml*

1400

>2000

1400

>2000

Varicella-zoster IgM*

negative

negative

negative

negative

HbA1c, %

7.6

7.1

7.1

8.9

Postherpetic neuralgia

yes

yes

no

no

Other relevant features

yes3

yes4

yes5

yes6

  1. 1Neuropathy, retinopathy, nephropathy; 2continuous subcutaneous insulin infusion with external insulin pump; 3insulin lipohypertrophy: lipoma with focal fibrosis and amyloid deposition (histologically proven); 4thyroid autoantibody positive, 5immunogenic thyroid atrophy; 6multiple allergies; *ELISA, enzyme-linked immunosorbent assay. CSII, continuous subcutaneous insulin infusion; IgG, immunoglobulin G; IgM, immunoglobulin M; HbA1c, glycated hemoglobin.