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Table 1 Clinical features of four diabetic patients with known history of herpes zoster, who never exhibited insulin-induced localized involutional lipoatrophy (LIL)

From: Insulin-induced localized lipoatrophy preceded by shingles (herpes zoster): a case report

Zoster patients without insulin-induced LIL
Gender male female male female
Age, years 56 60 59 79
Type of diabetes type-1 type-1 type-1 type-2
Duration of diabetes, years 37 36 28 19
Diabetic complications1 none none none none
Insulin therapy injections injections CSII2 injections
Application of Humalog™ no no no no
Varicella-zoster IgG, mU/ml* 1400 >2000 1400 >2000
Varicella-zoster IgM* negative negative negative negative
HbA1c, % 7.6 7.1 7.1 8.9
Postherpetic neuralgia yes yes no no
Other relevant features yes3 yes4 yes5 yes6
  1. 1Neuropathy, retinopathy, nephropathy; 2continuous subcutaneous insulin infusion with external insulin pump; 3insulin lipohypertrophy: lipoma with focal fibrosis and amyloid deposition (histologically proven); 4thyroid autoantibody positive, 5immunogenic thyroid atrophy; 6multiple allergies; *ELISA, enzyme-linked immunosorbent assay. CSII, continuous subcutaneous insulin infusion; IgG, immunoglobulin G; IgM, immunoglobulin M; HbA1c, glycated hemoglobin.