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Table 1 Platelet trends, associated events and treatments given to our patient over 12 years

From: A combination of bortezomib and rituximab yields a dramatic response in a woman with highly refractory immune thrombocytopenic purpura: a case report

Year

Platelet count (thousand/mm3)

Treatment

Events

2001

10

Rho(D) + prednisone

Menorrhagia

2002

19 to 160

Splenectomy

Menorrhagia

2003

30 to 150

Rituximab (weekly Ă—4) + high dose prednisone

 

2004

15 to 40

Danazol; rituximab (Ă—2)

 

2005

13 to 22

Vincristine (weekly Ă—4)

 

2006

20 to 30

Observation

Hysterectomy

2007

10 to 12

High pulse decadron; rituximabĂ—1; low dose cyclosporine 2.5mg/kg

Intracranial hemorrhage

2008

4 to 6

Intravenous immunoglobulin G; decadron; rituximab (weeklyĂ—4)

Ruptured ovarian cyst

2009

5 to 14

Eltrombopag 50mg to 75mg daily (Ă—3 months)

 

2010

9 to 12

Observation

 

2011

6 to 15

Observation

 

2012

4 to 10

Intravenous immunoglobulin G + prednisone + platelet transfusion

Intracranial hemorrhage

  

Romiplostim 8μg/kg to 10μg/kg

 

2013

12

Intravenous immunoglobulin + prednisone + platelet transfusion

Intracranial hemorrhage