Table 1 Well-established paraneoplastic antibodies with the associated paraneoplastic syndromes and associated cancers
From: Hodgkin’s lymphoma presenting as a complex paraneoplastic neurological syndrome: a case report
Antibody | Paraneoplastic neurological syndrome | Associated cancers |
|---|---|---|
Hu | Sensory neuropathy, encephalomyelitis | Neuroblastoma, SCLC |
Yo | Cerebellar degeneration | Breast, ovarian |
Tr | Cerebellar degeneration | Hodgkin’s lymphoma, thymoma |
Ma | Cerebellar, hypothalamic, limbic encephalitis | Testicular, breast, multiple other cancers |
Ri | Cerebellar degeneration, opsoclonus, brainstem encephalitis | Breast, gynecological, SCLC, Hodgkin’s, neuroblastoma |
Cancer-associated retinopathy | Photoreceptor degeneration | SCLC |
Lambert-Eaton myasthenic syndrome | Lambert-Eaton myasthenic syndrome | SCLC |
CV2 | Cerebellar degeneration, encephalomyelitis, peripheral neuropathy | Germ cell tumors of testis, SCLC |
Zic4 | Cerebellar degeneration | SCLC |
Voltage-gated potassium channels | Seizures, limbic encephalitis | Thymoma |
Amphiphysin | Stiff person syndrome, encephalomyelitis | Breast, lung cancer |
Acetylcholine receptor antibodies | Myasthenia gravis | Thymoma |
Recoverin | Retinopathy | SCLC |