International Neuroblastoma Pathology Classification | Tumor description | Original Shimada classification | Prognostic group |
---|---|---|---|
Neuroblastoma | Schwannian stroma-poor | Stroma-poor | |
Favorable | Favorable | Favorable | |
< 0.5 years | Poorly differentiating or differentiating and low or intermediate MKI tumor | ||
1.5 to 5 years | Differentiating and low MKI tumor | ||
Unfavorable | Unfavorable | Unfavorable | |
< 1.5 years | Undifferentiated tumor | ||
High MKI tumor | |||
1.5 to 5 years | Undifferentiated or poorly differentiated tumor | ||
Intermediate or high MKI tumor | |||
≥ 5 years | All tumors | ||
Ganglioneuroblastoma, intermixed | Schwannian stroma-rich | Stroma-rich intermixed (favorable) | Favorable |
Ganglioneuroma | Schwannian stroma-dominant | Favorable | |
Maturing | Well-differentiated (favorable) | ||
Mature | Ganglioneuroma | ||
Ganglioneuroblastoma, nodular | Composite Schwannian stroma-rich/stroma-dominant and stroma-poor | Stroma-rich nodular (unfavorable) | Unfavorable |