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Archived Comments for: Mitochondrial myopathy presenting as fibromyalgia: a case report

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  1. may be relevant for some patients diagnosed with myalgic encephalomyelitis or chronic fatigue syndrome

    Tom Kindlon, Irish ME/CFS Association

    30 July 2014

    I would like to thank the authors for taking the time to write up this case report, as well as thanking the patient for giving permission for the use of her story.

    I thought it was worth pointing out that the symptoms described by the authors and the patient would be quite similar to the symptoms patients with myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS) would report (1-7). I don't believe patients with an ME or CFS diagnosis are often assessed for a mitochondrial myopathy using the tests mentioned although a novel test did find evidence for mitochondrial dysfunction (8). At least two studies have found carnitine supplementation to be of benefit in patients diagnosed with CFS (9,10).

    Excessive acidosis on exercise has been found in patients (11,12). One study, looking for an association with enterovirus infection, found that 58% of CFS patients had an abnormal lactate response to subanaerobic threshold exercise test (13).

    CFS is increasingly recoognized as being heterogeneous (14). Despite its name, more symptoms than fatigue are generally associated with it (15). Mitochondrial problems could relevant for some patients even if they may not be relevant for all patients.


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    Competing interests

    I am the information officer of the Irish ME/CFS Association. All my work for the Irish ME/CFS Association is voluntary (i.e. unpaid)