The overview shows the destroyed muscular architecture and replacement of the muscle by connective tissue. ( A) Residual muscle fibers (asterisks) show pronounced myopathic changes while the connective tissue contains vacuoles with inflammatory infiltrates (arrows). Hematoxylin and eosin stain , ×10 magnification. ( B) Higher magnification reveals inflammatory infiltrates in the connective tissue and surrounding the vacuoles. Hematoxylin and eosin stain, ×40 magnification. ( C) Elastica van Gieson stain shows remaining muscle fibers (asterisks) with intermingled connective tissue and vacuoles, ×20 magnification. ( D) Multinucleated giant cells (arrows) and mononuclear infiltrates (arrowhead, cells negative for CD68) surround vacuoles, ×40 magnification.