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Table 1 Results of infectious and vasculitic and neoplastic studies performed on patient's first admission

From: Subacute herpes simplex virus type 1 encephalitis as an initial presentation of chronic lymphocytic leukemia and multiple sclerosis: a case report

Serum studies

Result (normal range or value)

CSF studies

Result (normal range)

Ehrlichia Ab titers

   

Anaplasma phagocytophilum IgG

<1:64 (<1:64)

Aerobic/anaerobic culture with Gram stain

No organisms seen, no growth at 3 days

Ehrlichia chaffeensis IgG

<1:64 (<1:64)

  

Bartonella Ab titers

   

Bartonella henselae IgG and IgM

<1:128 and <1:20 (<1:128 and <1:20)

Fungal preparation and culture

No fungal elements seen, no fungus recovered at 4 weeks

Bartonella quintana IgG and IgM

<1:128 and <1:20 (<1:128 and <1:20)

  

Lyme disease antigen PCR

Negative

AFB culture with smear

No AFB seen, no AFB recovered at 8 weeks.

RPR

Non-reactive

VDRL

Negative

Viral hepatitis panel

   

HA Ab (IgM)

Non-reactive

  

HBcAb (IgM) and HBsAg

Non-reactive

CMV PCR

Negative

HC Ab

Non-reactive

  

LCMV IgG and IgM Ab titer

<1:16 and <1:20 (<1:16 and <1:20)

LCMV IgG and IgM Ab titer

<1:1 and <1:1 (<1:1 and <1:1)

WNV IgG and IgM Ab

Negative

WNV IgG and IgM Ab

Negative

Toxoplasma IgG and IgM Ab titer

36 IU/mL and <0.55 (<4 and <0.55)

WNV PCR

Negative

Cryptococcal Ag

Negative

Enterovirus PCR

Negative

ESR (mm/hour)

9 (0 to 20)

VZV PCR

Negative

CRP (mg/dL)

0.2 (<0.5)

ACE (ACE units)

<4 (<4)

Expanded ANA screen: Abs to dsDNA, chromatin, Sm, RNP, Sm-RNP, Ribosomal protein, SS-A, SS-B, Jo-1, Scl-70, and Centromere B

Negative

  

Serum protein electrophoresis

No monoclonal bands identified

  
  1. Ab = antibody; ACE = angiotensin-converting enzyme; AFB = acid-fast bacilli; Ag = antigen; ANA = anti-nuclear antibody; CMV = cytomegalovirus; CRP = C-reactive protein; dsDNA = double-stranded DNA; ESR = erythrocyte sedimentation rate; HA = hepatitis A; HBcAb = anti-hepatitis B core antibody; HBsAg = hepatitis B surface antigen; LCMV = lymphocytic choriomeningitis virus; PCR = polymerase chain reaction; RNP = ribonucleoprotein; RPR = rapid plasma reagin; SS-A/B = Sjögren's syndrome antigen A/B; VDRL = Venereal Disease Research Laboratory; VZV = varicella zoster virus; WNV = West Nile virus.