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Table 1 The genetic heterogeneity of EGFR gene status in our patient.

From: Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: a case report

Sampling Time Origin Exon 19 deletiona L858R T790M
At initial diagnosis Bone Positive Negative Negative
At initial diagnosis Lungb Negative Negative Negative
Three years after diagnosis Brain Positive Negative Positive
Five years after diagnosis Lungc Positive Positive Negative
Six years after diagnosis Lungc Positive Negative Positive
  1. aI744-R748del, E749I (GAA to ATT), and A750K (GCA to AAA). bPrimary tumor. cPulmonary metastatic nodule.