Spatial and temporal genetic heterogeneity of epidermal growth factor receptor gene status in a patient with non-small cell lung cancer: a case report

Table 1 The genetic heterogeneity of EGFR gene status in our patient.

Sampling Time	Origin	Exon 19 deletion^a	L858R	T790M
At initial diagnosis	Bone	Positive	Negative	Negative
At initial diagnosis	Lung^b	Negative	Negative	Negative
Three years after diagnosis	Brain	Positive	Negative	Positive
Five years after diagnosis	Lung^c	Positive	Positive	Negative
Six years after diagnosis	Lung^c	Positive	Negative	Positive

^aI744-R748del, E749I (GAA to ATT), and A750K (GCA to AAA). ^bPrimary tumor. ^cPulmonary metastatic nodule.

ISSN: 1752-1947